Actinomycin D for Wilms's tumour.
نویسندگان
چکیده
منابع مشابه
Actinomycin D in Wilm's Tumour: Treatment of Lung Metastases.
This paper discusses recent world trends in the treatment of Wilms' tumour, particularly as exemplified by their impact on practice at the Royal Children's Hospital, Melbourne. Following the use of actinomycin D in the therapy of lung metastases of Wilms' tumour (see below), it became apparent that this drug was able, at times, to inhibit their growth and, more rarely, to cause their complete r...
متن کاملActinomycin D in Wilms' Tumour: Treatment of Lung Metastases* By
This paper discusses recent world trends in the treatment of Wilms' tumour, particularly as exemplified by their impact on practice at the Royal Children's Hospital, Melbourne. Following the use of actinomycin D in the therapy of lung metastases of Wilms' tumour (see below), it became apparent that this drug was able, at times, to inhibit their growth and, more rarely, to cause their complete r...
متن کاملExperimental studies with actinomycin D.
Actinomycin D has been tested on mouse tu mors, with varying degrees of success, as an anti-neoplastic agent. Dramatic inhibition of some ascites (mouse) tumors has been reported by Sugiura (14) and Gregory et al. (6). Reilly (11) and Sugiura (14) are in agreement that actino-mycin D has slight antineoplastic activity against S-180, and Farber (3) demonstrated antitumor activity against the mal...
متن کاملSuppression of erythropoiesis by actinomycin D. I. Evolutional change of hemopoiesis by actinomycin D.
For the purpose of revealing whether the sensitivity of the erythropoiesis to actinomycin D (AMD) differs among different animal species, and to see the acting site of AMD on erythroid cell specialization stage, the author observed the hourly change of the blood cell counts and bone marrow cells after AMD administration to mice, rats and rabbits, and obtained the following results: 1. The data ...
متن کاملAKT mediates actinomycin D-induced p53 expression
At high cytotoxic concentrations, actinomycin D (ActD) blocks transcription, decreasing levels of MDM2 and thus causing p53 stabilization. At low cytostatic concentrations, ActD causes ribosomal stress, which decreases MDM2 activity, resulting in p53 stabilization and activation. ActD can thus be used for p53-based cyclotherapy. We analyzed pathways mediating ActD-induced p53 expression. Inhibi...
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ژورنال
عنوان ژورنال: BMJ
سال: 1973
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5867.661-a